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lotrlockedwhovian:

punkrockdirection:

sometimes i forget im a real person

this is such a weird thing but I understand.

(via kittyorleans)

Source: punkrockdirection
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Italian Girl with Flowers - Joaquin Sorolla y Bastida

1886

(via elfpen)

Source: fleurdulys
Photo Set

rachellebutler:

Closeups of Beethoven’s penmanship

Edits by lvbandmore.blogspot.com

(via haveamagicalday-x)

Source: rachellebutler
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jem-love13:

Did you say clouds and sunsets?

(via popsicle-stick)

Source: jem-love13
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immense-immunology-insight:

7 reasons why cancer cells are immortal

1. Cancer cells don’t age.
Normal cells go through senescence through shortening of telomeres with every cell division. Cancer cells however have telomerase that will sustain the telomere length of the chromosomes rendering the cell virtually immortal.

2. Cancer cells have a way around apoptosis, their programmed cell death.
They overexpress antiapoptotic molecules and can multiply forever.

3. The Grim Reaper can’t recognize them.
The Natural killer cells, or the Grim Reaper; are supposed to cause death of the tumor cells. However, cancer cells remain undetected because they down regulate their MHC proteins or use decoy proteins to look innocent.

4. If recognized, the Grim Reaper can’t kill them.
Tumor cells block the death receptor pathway and directly interfere with the perforin/granzyme pathway. That is why, natural killer cells fail to kill them.

5. Cancer cells don’t need anything.
Cancer cells are self sufficient on growth factors. This means that they can continue to proliferate and divide independently, as opposed to normal cells that need external growth factors.

6. And if they do need something, they order it to come to them.
When cancer cells need of oxygen and nutrients, they stimulate angiogenesis; which is inducing growth of new blood vessels.

7. They have metabolic super powers.
The metabolism of malignant cells is usually more anaerobic than that of normal cells and is greatly accelerated. Malignant cells have the ability to withstand hypoxic conditions. They have increased glucose and amino acid uptake. In addition, they have high levels of hexokinase increasing their glucose utilization.

(via cardiacattack)

Source: immense-immunology-insight.blogspot.in
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pwopersonic:

there are so many posts about wanting certain things from stories

'a female villain not motivated by men or by hating other girls'

'a situation where it's the man who doesn't know how to use a gun and a female character has to teach him/deal with his lack of knowledge'

'male character likes traditionally feminine things and isn't shamed for it'

artemis fowl is literally all of that

like

that thing exists

artemis fowl

(via popsicle-stick)

Source: pwopersonic
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tennants-hair:

i found myself on omegle

image

image

like are you kidding me there were 44,000 people online but i’m still forever alone

(via pizza)

Source: tennants-hair
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fortheloveofscrubs:

Don’t do it for your application. Don’t do it for it to “look good” to a medical schools admission committee, do it for you. Do it because you want to do it and you enjoy doing it, and trust me it will be so much better.

Source: fortheloveofscrubs
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Photo Set

landofmerlin:

Guinevere fest: day #6

Once and Future: Queen Guinevere
Source: landofmerlin
Quote

"Your brain is wired for survival, not happiness. That is why it keeps bringing up negative emotions, past mistakes and worries about the future. Because of this wiring, you can get stuck in repetitive cycles of self-criticism, worry and fear that interfere with your ability to enjoy the present moment."

Source: salon
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genius-of-a-fake-suicide:

i-am-greg-lestrade:

mid0nz:

mid0nz:

moriarty:

cinnabutt:

wwankin:

hey doesn’t Sherlock have a best friend or something in this show?

John Wazowski

image

JOHN WAZOWSKI

The hiatus continues

(via merlinswarlock)

Source: wwankin
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Chat
  • Artemis: Holly, there’s something ... I should say; I-I’ve meant to say always and then never have. Since it’s unlikely we’ll ever meet again, I might as well say it now.
  • Artemis: Artemis is actually a girl’s name.
Source: artemisfowlstolemysoul